Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HLCL-61 hydrochloride (HLCL-61 HCL) 是小分子蛋白精氨酸甲基转移酶 5 抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 185 | 现货 | ||
5 mg | ¥ 413 | 现货 | ||
10 mg | ¥ 622 | 现货 | ||
25 mg | ¥ 1,080 | 现货 | ||
50 mg | ¥ 1,620 | 现货 | ||
100 mg | ¥ 2,490 | 现货 | ||
200 mg | ¥ 3,680 | 现货 | ||
500 mg | ¥ 5,880 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 455 | 现货 |
产品描述 | HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. |
靶点活性 | PRMT5:16.74 μM |
体外活性 | HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h[1]. |
细胞实验 | CD11b expression is tested by flow cytometry on cells treated with DMSO or HLCL-61 (25 and 50 μM) for 48 h.(Only for Reference) |
别名 | HLCL61, HLCL-61 HCL |
分子量 | 380.91 |
分子式 | C23H24N2O·ClH |
CAS No. | 1158279-20-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (131.26 mM), Heating is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 15 mg/mL (32.7 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 2.6253 mL | 13.1265 mL | 26.2529 mL | 65.6323 mL |
5 mM | 0.5251 mL | 2.6253 mL | 5.2506 mL | 13.1265 mL | |
10 mM | 0.2625 mL | 1.3126 mL | 2.6253 mL | 6.5632 mL | |
20 mM | 0.1313 mL | 0.6563 mL | 1.3126 mL | 3.2816 mL | |
DMSO | 50 mM | 0.0525 mL | 0.2625 mL | 0.5251 mL | 1.3126 mL |
100 mM | 0.0263 mL | 0.1313 mL | 0.2625 mL | 0.6563 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
HLCL-61 hydrochloride 1158279-20-9 Apoptosis Chromatin/Epigenetic Histone Methyltransferase HLCL61 HLCL-61 HCL HLCL-61 inhibit HLCL 61 hydrochloride HLCL61 Hydrochloride HLCL 61 Hydrochloride HLCL-61 Hydrochloride HLCL 61 HLCL61 hydrochloride Inhibitor inhibitor